Peer-reviewed journal articles, newest first. Titles, author lists and journal details are reproduced exactly as published and are not translated.
2026Cornea & KeratoconusCorneal Biomechanics & DiagnosticsClinical prevalence study
Prevalence of floppy eyelid syndrome and keratoconus in Egyptian patients with obstructive sleep apnea
Islam S. H. Ahmed, Amir Ramadan, Khalfan M. Khamis, Ahmed Yassin Bahgat, Amr Said
International Ophthalmology. 2026;46(1):195
Floppy eyelid syndrome and keratoconus screened by corneal tomography in 600 patients with obstructive sleep apnoea.
Full summary, clinical relevance and identifiers
Summary of the published research
Six hundred patients with confirmed obstructive sleep apnoea (OSA; 1,200 eyes, mean age 55.0 years) were examined by two ophthalmologists for floppy eyelid syndrome (FES) and had bilateral corneal tomography (Scansys TA517) analysed with the manufacturer's keratoconus grading software. FES was identified in 96 eyes (8%) and keratoconus in 24 eyes (2%). Both conditions were associated with severe OSA on univariate analysis, but these associations were not significant in the multivariate model after adjusting for age, gender and body mass index (BMI).
Based on the published abstract.
Clinical relevance
Supports including an eye examination in the multidisciplinary care of patients with sleep apnoea. Because the association with OSA severity disappeared after adjustment, the study does not show that sleep apnoea causes keratoconus; systemic factors such as BMI may play a mediating role.
Educational interpretation — not a finding of the study unless stated.
Prof. Said is listed as the fifth and last of 5 authors.
DOI: 10.1007/s10792-026-04073-z · PMID: 41949668
2024Corneal Biomechanics & DiagnosticsCornea & KeratoconusCross-sectional study
Corneal topography findings among patients with thyroid dysfunction
Marwa A. S. Ahmed, Amr Said
Tanta Medical Journal. 2024;52(3):253–257
Corneal topography in 200 patients with thyroid dysfunction, compared with thyroid hormone levels.
Full summary, clinical relevance and identifiers
Summary of the published research
Cross-sectional study of 200 patients with thyroid dysfunction (129 hypothyroid, 71 hyperthyroid) attending the Endocrinology Clinic of the Faculty of Medicine, Alexandria University. Corneal topography was examined with TMS, and serum TSH, free T4 and free T3 were measured. No relation was found between keratometry readings or corneal thickness and thyroid hormone levels. The authors reported topographic changes favouring a thin and steep cornea rather than true keratoconus.
Based on the published abstract.
Clinical relevance
The authors conclude that corneal topography in patients with thyroid disease needs cautious analysis, especially before refractive surgery. The journal is not indexed in PubMed; the record is verified through its DOI registration.
Educational interpretation — not a finding of the study unless stated.
Prof. Said is listed as the second and last of 2 authors.
DOI: 10.4103/tmj.tmj_19_24 · Not indexed in PubMed
2023Cornea & KeratoconusRefractive SurgeryProspective study
Intraocular pressure after combined photorefractive keratectomy and corneal collagen cross-linking for keratoconus
Karim Mahmoud Nabil, Ahmed Abdel Karim Elmassry, Silas Ntakarusho, Amr Ahmed Said
International Ophthalmology. 2023;43(12):4837–4849
Intraocular pressure measured for 12 months after combined PRK and cross-linking for early keratoconus.
Full summary, clinical relevance and identifiers
Summary of the published research
Prospective study of 64 eyes (34 patients) with stage 1–2 keratoconus treated with combined wavefront-optimised PRK and corneal collagen cross-linking (CXL), with two control groups: PRK alone for myopia (110 eyes) and CXL alone (36 eyes). IOP was recorded before surgery and at 3, 6 and 12 months. Preoperative IOP was significantly lower in both keratoconus groups than in the PRK group. At 3 months there was no significant difference between groups; at 6 months IOP in the CXL group was significantly higher than in both other groups, and at 12 months it was significantly higher than in the PRK group.
Based on the published abstract.
Clinical relevance
Measured IOP is influenced by corneal thickness and structure, so pressure readings taken after corneal procedures need careful interpretation — relevant to long-term follow-up and glaucoma screening in treated keratoconus. Follow-up in this study was 12 months.
Educational interpretation — not a finding of the study unless stated.
Prof. Said is listed as the fourth and last of 4 authors.
DOI: 10.1007/s10792-023-02886-w · PMID: 37861937 · PMCID: PMC10724307 (free full text)
2020Refractive SurgeryRetrospective study
Long-Term Refractive Outcome of Small Incision Lenticule Extraction in Very High Myopia
Ahmed Elmassry, Osama Ibrahim, Ihab Osman, Amr Said, Moataz Sabry, Mohammed Seifelnasr, Karim Gaballah, Moones Abdalla
Cornea. 2020;39(6):669–673
Three-year results of SMILE in 495 eyes with very high myopia (−10 to −14 D).
Full summary, clinical relevance and identifiers
Summary of the published research
Retrospective, non-comparative analysis of 495 eyes of 270 patients treated with ReLEx SMILE for a mean spherical myopia of −12.84 ± 2.47 D (range −10.0 to −14.0 D) with up to −4.0 D of astigmatism, followed for 3 years. Visual and refractive parameters remained the same or changed minimally between the early and final visits; the spherical error showed a small but statistically significant myopic change, which the authors judged to have an insignificant visual impact. At the final visit, approximately 94% of patients had unchanged corrected distance visual acuity or gained one or more lines. A correction (erratum) to this article has been published.
Based on the published abstract.
Clinical relevance
Relevant to assessing whether SMILE is suitable for people with very high myopia. The study had no comparison group. Because a correction has been published, figures should be checked against the original article and its erratum before they are quoted.
Educational interpretation — not a finding of the study unless stated.
Prof. Said is listed as the fourth of 8 authors.
DOI: 10.1097/ICO.0000000000002288 · PMID: 32118668 · Erratum: Cornea. 2020;39(11):e28 · PMID 32740007
2020Corneal Biomechanics & DiagnosticsCross-sectional study
Corneal biomechanics in different age groups
Ahmed Abdel Karim El Massry, Amr Ahmed Said, Ihab Mohamed Osman, Amr Saad Bessa, Mohammed Ahmed Elmasry, Eman Nabil Elsayed, Nader Hussein Lotfy Bayoumi
International Ophthalmology. 2020;40(4):967–974
Age-stratified corneal biomechanical values (Ocular Response Analyzer) in 997 normal eyes.
Full summary, clinical relevance and identifiers
Summary of the published research
Cross-sectional survey of 997 eyes of 508 normal individuals presenting for routine examination at Alexandria Main University Hospital, measured with the Ocular Response Analyzer and stratified by decade of age (10–20 to over 50 years). Corneal hysteresis (CH) and corneal resistance factor (CRF) showed a statistically significant negative correlation with age. Corneal-compensated IOP (IOPcc) showed a fairly constant trend across age groups, whereas Goldmann-correlated IOP (IOPg) declined initially and then rose gradually.
Based on the published abstract.
Clinical relevance
Provides age-specific normal values for corneal biomechanical measurements in an Egyptian population — useful context when these readings are interpreted in keratoconus screening or before refractive surgery. The study used a single device and a cross-sectional design.
Educational interpretation — not a finding of the study unless stated.
Prof. Said is listed as the second of 7 authors.
DOI: 10.1007/s10792-019-01273-8 · PMID: 31916064
2020Cataract & Intraocular Lens SurgeryRetrospective comparative study
Comparison between refractive outcomes of femtosecond laser-assisted cataract surgery and standard phacoemulsification
Mohamed Shafik Shaheen, Amir AbouSamra, Hany Ahmed Helaly, Amr Said, Ahmed Elmassry
BMC Ophthalmology. 2020;20:1
Femtosecond laser-assisted cataract surgery versus conventional phacoemulsification in 100 eyes. Academic research only; femtosecond laser-assisted cataract surgery is not currently offered at the clinic, which performs phacoemulsification.
Full summary, clinical relevance and identifiers
Summary of the published research
Retrospective study of 100 eyes: 50 had femtosecond laser-assisted cataract surgery (FLACS, Victus platform) and 50 had conventional phacoemulsification, with visual, refractive and aberrometric evaluation before and 6 months after surgery. Uncorrected distance visual acuity improved in both groups, and safety indices were high in both (1.777 FLACS; 1.744 conventional). Mean surgically induced astigmatism was lower with FLACS (0.35 vs 0.901 D, p = 0.015). Total aberrations favoured the conventional group, low-order aberrations were significantly lower with FLACS, and the difference in higher-order aberrations was not statistically significant.
Based on the published abstract.
Clinical relevance
Gives a balanced picture of what femtosecond laser assistance changes in routine cataract surgery: both techniques were safe and effective in this series. The study was retrospective, used one laser platform and had 6 months of follow-up.
Educational interpretation — not a finding of the study unless stated.
Prof. Said is listed as the fourth of 5 authors.
DOI: 10.1186/s12886-019-1277-9 · PMID: 31898534 · PMCID: PMC6941343 (free full text)
2020Cornea & KeratoconusProspective multicentre randomised trial
Standard cross-linking protocol versus accelerated and transepithelial cross-linking protocols for treatment of paediatric keratoconus: a 2-year comparative study
Mohammed Iqbal, Ahmed Elmassry, Hisham Saad, Ahmed A. M. Gad, Ola Ibrahim, Noha Hamed, Ahmed Saeed, Ahmad S. Khalil, Mohamed Tawfik, Amr Said, Ibrahim Amer, Asaad Nooreldin, Omar Said, Mohamed Reffat, Seif Anwar, Amani Badawi
Acta Ophthalmologica. 2020;98(3):e352–e362 (published online 25 October 2019)
Three cross-linking protocols compared in 136 children with progressive keratoconus over 2 years.
Full summary, clinical relevance and identifiers
Summary of the published research
Prospective multicentre controlled trial of 271 eyes of 136 children with grade 1–3 progressive keratoconus, randomised to standard epithelium-off cross-linking (SCXL, n = 91, control), accelerated epithelium-off cross-linking (ACXL, n = 92) or transepithelial epithelium-on cross-linking (TCXL, n = 88), with assessment at 6, 12 and 24 months. At 1 year ACXL and SCXL did not differ significantly, but during year 2 ACXL regressed while SCXL continued to improve. After 2 years there were significant differences in all visual, refractive and keratometric measures in favour of SCXL. Keratoconus progressed in 5.4% of patients after ACXL and 28.4% after TCXL, and in none after SCXL. Vernal keratoconjunctivitis was documented in 43.3% of eyes that progressed.
Based on the published abstract.
Clinical relevance
Directly relevant to choosing a cross-linking protocol for children: the authors concluded that the standard protocol is preferable for paediatric keratoconus, while noting that the refractive changes after it were unpredictable. Follow-up was 2 years.
Educational interpretation — not a finding of the study unless stated.
Prof. Said is listed as the tenth of 16 authors.
DOI: 10.1111/aos.14275 · PMID: 31654497 · PMCID: PMC7216930 (free full text)
2019Cataract & Intraocular Lens SurgeryRetrospective comparative study
Comparison between Refractive Outcome of Primary Piggyback Intraocular Lens versus Secondary Lens Iris Claw Lens in Posterior Microphthalmos
Abdelhamid Elhofi, Hany Ahmed Helaly, Amr Said
Journal of Ophthalmology. 2019;2019:1356982
Lens surgery options for high hyperopia in very short eyes (posterior microphthalmos), followed for 36 months.
Full summary, clinical relevance and identifiers
Summary of the published research
Retrospective comparative study of 60 eyes of 30 patients with bilateral posterior microphthalmos and high axial hyperopia who underwent refractive lens exchange: one group received primary piggyback IOLs, the other the maximum available IOL power followed by a secondary Artisan iris-fixated IOL. The groups were comparable in age, axial length, refraction and keratometry. At 36 months, 20% and 73% of eyes were within ±0.5 D of the intended refraction (piggyback vs secondary iris-claw), and 53% and 93% within ±1.0 D (p = 0.001). There was no significant difference in corrected distance visual acuity.
Based on the published abstract.
Clinical relevance
Relevant to planning lens surgery in very short eyes, where standard IOL powers may be insufficient. The study was retrospective and, because the condition is uncommon, the number of eyes was limited.
Educational interpretation — not a finding of the study unless stated.
Prof. Said is listed as the third and last of 3 authors.
DOI: 10.1155/2019/1356982 · PMID: 30895155 · PMCID: PMC6393898 (free full text)
2016Cornea & KeratoconusRefractive SurgeryProspective interventional case series
Combined femtosecond laser-assisted intracorneal ring segment implantation and corneal collagen cross-linking for correction of keratoconus
Osama Ibrahim, Ahmed Elmassry, Amr Said, Moones Abdalla, Hazem El Hennawi, Ihab Osman
Clinical Ophthalmology. 2016;10:521–526
Femtosecond laser-assisted Keraring segments combined with cross-linking in 160 keratoconic eyes.
Full summary, clinical relevance and identifiers
Summary of the published research
Prospective, non-comparative interventional case series of 160 eyes of 100 adults with keratoconus, poor best-corrected visual acuity (below 0.7) and contact lens intolerance, treated with femtosecond laser-assisted Keraring intrastromal corneal ring segment insertion and corneal collagen cross-linking. At 6 months, mean uncorrected and best-corrected visual acuity, spherical equivalent and keratometry (K1 and K2) improved significantly (P < 0.001). Pachymetry did not differ significantly from preoperative values.
Based on the published abstract.
Clinical relevance
Supports combining ring segments with cross-linking as one option for selected adults with keratoconus who cannot tolerate contact lenses. Follow-up was 6 months and there was no comparison group, so the study does not address long-term stability.
Educational interpretation — not a finding of the study unless stated.
Prof. Said is listed as the third of 6 authors. The published article names him as the corresponding author.
DOI: 10.2147/OPTH.S97158 · PMID: 27041991 · PMCID: PMC4809308 (free full text)
No publications match this search.